News | Laboratory of Systems Biology

1st Oct 2014

Published paper: Where energy compartments shape communication in heart cells

The location of energetic compartments affects energetic communication in cardiomyocytes

Rikke Birkedal, Martin Laasmaa, Marko Vendelin

Front Physiol, 2014; 5: 376.

PMID: 25324784
DOI: 10.3389/fphys.2014.00376

Significance

Heart cells must continuously match energy production to t...

1st Sep 2014

Published paper: Glycolysis powers Na+/K+-ATPase in heart cells

Tight coupling of Na+/K+-ATPase with glycolysis demonstrated in permeabilized rat cardiomyocytes

Mervi Sepp, Niina Sokolova, Svetlana Jugai, Merle Mandel, Pearu Peterson, Marko Vendelin

PLoS One, 2014; 9(6): e99413.

PMID: 24932585
DOI: 10.1371/journal.pone.0099413

Significance

Hea...

1st Dec 2013

Published paper: ADP protects stressed heart mitochondria

ADP protects cardiac mitochondria under severe oxidative stress

Niina Sokolova, Shi Pan, Sarah Provazza, Gisela Beutner, Marko Vendelin, Rikke Birkedal, Shey-Shing Sheu

PLoS One, 2013; 8(12): e83214.

PMID: 24349464
DOI: 10.1371/journal.pone.0083214

Significance

Mitochondria supply...

1st Aug 2013

Published paper: Creatine deficiency leaves cardiac energy organization intact

Unchanged mitochondrial organization and compartmentation of high-energy phosphates in creatine-deficient GAMT-/- mouse hearts

Jelena Branovets, Mervi Sepp, Svetlana Kotlyarova, Natalja Jepihhina, Niina Sokolova, Dunja Aksentijevic, Craig A Lygate, Stefan Neubauer, Marko Vendelin, Rikke Birkedal

...

1st Mar 2013

Published paper: Robust image-based sarcomere measurements during heart-cell contraction

Real-time determination of sarcomere length of a single cardiomyocyte during contraction

Pearu Peterson, Mari Kalda, Marko Vendelin

Am J Physiol Cell Physiol, 2013 Mar; 304(6): C519-31.

PMID: 23255581
DOI: 10.1152/ajpcell.00032.2012

Significance

Measuring the spacing of the force-...

1st Dec 2012

Published paper: Heart energy model tests the limits of oxygen-labeling flux measurements

Sensitivity analysis of flux determination in heart by H₂ ¹⁸O -provided labeling using a dynamic Isotopologue model of energy transfer pathways

David W Schryer, Pearu Peterson, Ardo Illaste, Marko Vendelin

PLoS Comput Biol, 2012; 8(12): e1002795.

PMID: 23236266
DOI: 10.1371/journal.pcbi...

1st Mar 2012

Published paper: Simulations model the mitochondrial creatine kinase-ANT partnership

Molecular dynamics simulations of creatine kinase and adenine nucleotide translocase in mitochondrial membrane patch

Jaanus Karo, Pearu Peterson, Marko Vendelin

J Biol Chem, 2012 Mar 02; 287(10): 7467-76.

PMID: 22241474
DOI: 10.1074/jbc.M111.332320

Significance

Mitochondria make t...

1st Feb 2012

Published paper: Internal barriers organize molecular movement in heart cells

Analysis of molecular movement reveals latticelike obstructions to diffusion in heart muscle cells

Ardo Illaste, Martin Laasmaa, Pearu Peterson, Marko Vendelin

Biophys J, 2012 Feb 22; 102(4): 739-48.

PMID: 22385844
DOI: 10.1016/j.bpj.2012.01.012

Significance

Molecules must move th...

1st Nov 2011

Published paper: Heart-cell imaging reveals intracellular barriers to molecular diffusion

Permeabilized rat cardiomyocyte response demonstrates intracellular origin of diffusion obstacles

Natalja Jepihhina, Nathalie Beraud, Mervi Sepp, Rikke Birkedal, Marko Vendelin

Biophys J, 2011 Nov 02; 101(9): 2112-21.

PMID: 22067148
DOI: 10.1016/j.bpj.2011.09.025

Significance

Hear...

1st Aug 2011

Published paper: Automatic regularization advances confocal image deconvolution

Application of regularized Richardson-Lucy algorithm for deconvolution of confocal microscopy images

M Laasmaa, M Vendelin, P Peterson

J Microsc, 2011 Aug; 243(2): 124-40.

PMID: 21323670
DOI: 10.1111/j.1365-2818.2011.03486.x

Significance

Confocal microscopy reduces blur from out-o...