News

The latest updates from our laboratory.

Published paper: Creatine deficiency leaves cardiac energy organization intact

Unchanged mitochondrial organization and compartmentation of high-energy phosphates in creatine-deficient GAMT-/- mouse hearts

Jelena Branovets, Mervi Sepp, Svetlana Kotlyarova, Natalja Jepihhina, Niina Sokolova, Dunja Aksentijevic, Craig A Lygate, Stefan Neubauer, Marko Vendelin, Rikke Birkedal

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Published paper: Heart energy model tests the limits of oxygen-labeling flux measurements

Sensitivity analysis of flux determination in heart by H₂ ¹⁸O -provided labeling using a dynamic Isotopologue model of energy transfer pathways

David W Schryer, Pearu Peterson, Ardo Illaste, Marko Vendelin

PLoS Comput Biol, 2012; 8(12): e1002795.

Published paper: Simulations model the mitochondrial creatine kinase-ANT partnership

Molecular dynamics simulations of creatine kinase and adenine nucleotide translocase in mitochondrial membrane patch

Jaanus Karo, Pearu Peterson, Marko Vendelin

J Biol Chem, 2012 Mar 02; 287(10): 7467-76.

Significance

Mitochondria make t...

Published paper: Internal barriers organize molecular movement in heart cells

Analysis of molecular movement reveals latticelike obstructions to diffusion in heart muscle cells

Ardo Illaste, Martin Laasmaa, Pearu Peterson, Marko Vendelin

Biophys J, 2012 Feb 22; 102(4): 739-48.

Significance

Molecules must move th...

Published paper: Automatic regularization advances confocal image deconvolution

Application of regularized Richardson-Lucy algorithm for deconvolution of confocal microscopy images

M Laasmaa, M Vendelin, P Peterson

J Microsc, 2011 Aug; 243(2): 124-40.

Significance

Confocal microscopy reduces blur from out-o...