News

Cardiac muscle regulatory units are predicted to interact stronger than neighboring cross-bridges

Mari Kalda, Marko Vendelin

Sci Rep, 2020 Mar 26; 10(1): 5530.

• PMID: 32218497
• DOI: 10.1038/s41598-020-62452-7

Significance

Heart muscle cells respond steeply to small increases in calc...

Energy-efficiency of Cardiomyocyte Stimulation with Rectangular Pulses

Martin Laasmaa, Pengfei Lu, Mladen Veletić, William E Louch, Jacob Bergsland, Ilangko Balasingham, Marko Vendelin

Sci Rep, 2019 Sep 16; 9(1): 13307.

• PMID: 31527628
• DOI: 10.1038/s41598-019-49791-w

Significance

P...

Respiration of permeabilized cardiomyocytes from mice: no sex differences, but substrate-dependent changes in the apparent ADP-affinity

Niina Karro, Martin Laasmaa, Marko Vendelin, Rikke Birkedal

Sci Rep, 2019 Aug 29; 9(1): 12592.

• PMID: 31467353
• DOI: 10.1038/s41598-019-48964-x

Signi

IOCBIO Sparks detection and analysis software

Martin Laasmaa, Niina Karro, Rikke Birkedal, Marko Vendelin

PeerJ, 2019; 7: e6652.

• PMID: 30956900
• DOI: 10.7717/peerj.6652

Significance

Calcium sparks are brief, localized releases of calcium that help control heart-cell contraction and...

Revealing calcium fluxes by analyzing inhibition dynamics in action potential clamp

Martin Laasmaa, Rikke Birkedal, Marko Vendelin

J Mol Cell Cardiol, 2016 Nov; 100: 93-108.

• PMID: 27702573
• DOI: 10.1016/j.yjmcc.2016.08.015

Significance

Calcium drives each heartbeat, but several tig...

Metabolic compartmentation in rainbow trout cardiomyocytes: coupling of hexokinase but not creatine kinase to mitochondrial respiration

Niina Karro, Mervi Sepp, Svetlana Jugai, Martin Laasmaa, Marko Vendelin, Rikke Birkedal

J Comp Physiol B, 2017 Jan; 187(1): 103-116.

• PMID: 27522222
• DOI:...

Restricted ADP movement in cardiomyocytes: Cytosolic diffusion obstacles are complemented with a small number of open mitochondrial voltage-dependent anion channels

Päivo Simson, Natalja Jepihhina, Martin Laasmaa, Pearu Peterson, Rikke Birkedal, Marko Vendelin

J Mol Cell Cardiol, 2016 Aug; 97:...

Cross-Bridge Group Ensembles Describing Cooperativity in Thermodynamically Consistent Way

Mari Kalda, Pearu Peterson, Marko Vendelin

PLoS One, 2015; 10(9): e0137438.

• PMID: 26361396
• DOI: 10.1371/journal.pone.0137438

Significance

Muscle contraction depends on molecular motors called...

The location of energetic compartments affects energetic communication in cardiomyocytes

Rikke Birkedal, Martin Laasmaa, Marko Vendelin

Front Physiol, 2014; 5: 376.

• PMID: 25324784
• DOI: 10.3389/fphys.2014.00376

Significance

Heart cells must continuously match energy production to t...

Tight coupling of Na+/K+-ATPase with glycolysis demonstrated in permeabilized rat cardiomyocytes

Mervi Sepp, Niina Sokolova, Svetlana Jugai, Merle Mandel, Pearu Peterson, Marko Vendelin

PLoS One, 2014; 9(6): e99413.

• PMID: 24932585
• DOI: 10.1371/journal.pone.0099413

Significance

Hea...