News

IOCBIO Sparks software has been updated to 1.2.0. The new version fixes an issue with displaying images on newer installations. It also includes enhancements for scripts that let you start the analysis of a specific experiment by specifying its experiment ID. In addition, you can start it in read-...

Marker enzyme activities in hindleg from creatine-deficient AGAT and GAMT KO mice - differences between models, muscles, and sexes

Karina Barsunova, Marko Vendelin, Rikke Birkedal

Sci Rep, 2020 May 14; 10(1): 7956.

• PMID: 32409787
• DOI: 10.1038/s41598-020-64740-8

Significance

Creati...

Cardiac muscle regulatory units are predicted to interact stronger than neighboring cross-bridges

Mari Kalda, Marko Vendelin

Sci Rep, 2020 Mar 26; 10(1): 5530.

• PMID: 32218497
• DOI: 10.1038/s41598-020-62452-7

Significance

Heart muscle cells respond steeply to small increases in calc...

Energy-efficiency of Cardiomyocyte Stimulation with Rectangular Pulses

Martin Laasmaa, Pengfei Lu, Mladen Veletić, William E Louch, Jacob Bergsland, Ilangko Balasingham, Marko Vendelin

Sci Rep, 2019 Sep 16; 9(1): 13307.

• PMID: 31527628
• DOI: 10.1038/s41598-019-49791-w

Significance

P...

Respiration of permeabilized cardiomyocytes from mice: no sex differences, but substrate-dependent changes in the apparent ADP-affinity

Niina Karro, Martin Laasmaa, Marko Vendelin, Rikke Birkedal

Sci Rep, 2019 Aug 29; 9(1): 12592.

• PMID: 31467353
• DOI: 10.1038/s41598-019-48964-x

Signi

IOCBIO Sparks detection and analysis software

Martin Laasmaa, Niina Karro, Rikke Birkedal, Marko Vendelin

PeerJ, 2019; 7: e6652.

• PMID: 30956900
• DOI: 10.7717/peerj.6652

Significance

Calcium sparks are brief, localized releases of calcium that help control heart-cell contraction and...

Revealing calcium fluxes by analyzing inhibition dynamics in action potential clamp

Martin Laasmaa, Rikke Birkedal, Marko Vendelin

J Mol Cell Cardiol, 2016 Nov; 100: 93-108.

• PMID: 27702573
• DOI: 10.1016/j.yjmcc.2016.08.015

Significance

Calcium drives each heartbeat, but several tig...

Restricted ADP movement in cardiomyocytes: Cytosolic diffusion obstacles are complemented with a small number of open mitochondrial voltage-dependent anion channels

Päivo Simson, Natalja Jepihhina, Martin Laasmaa, Pearu Peterson, Rikke Birkedal, Marko Vendelin

J Mol Cell Cardiol, 2016 Aug; 97:...

Metabolic compartmentation in rainbow trout cardiomyocytes: coupling of hexokinase but not creatine kinase to mitochondrial respiration

Niina Karro, Mervi Sepp, Svetlana Jugai, Martin Laasmaa, Marko Vendelin, Rikke Birkedal

J Comp Physiol B, 2017 Jan; 187(1): 103-116.

• PMID: 27522222
• DOI:...

Cross-Bridge Group Ensembles Describing Cooperativity in Thermodynamically Consistent Way

Mari Kalda, Pearu Peterson, Marko Vendelin

PLoS One, 2015; 10(9): e0137438.

• PMID: 26361396
• DOI: 10.1371/journal.pone.0137438

Significance

Muscle contraction depends on molecular motors called...