News

Congratulations to three students from the Laboratory of Systems Biology who defended their master's theses in Applied Physics on 5 June.

Marten Pärg defended Implementing 3D Imaging in Single Molecule Localization Microscopy with Astigmatism. His work implemented three-dimensional super-resolut...

Statistical analysis of fluorescence intensity transients with Bayesian methods.

Hamed Karimi, Martin Laasmaa, Margus Pihlak, Marko Vendelin

Sci Adv, 2025 Apr 18; 11(16): eads4609.

• PMID: 40249821
• DOI: 10.1126/sciadv.ads4609

Abstract

Molecular movement and interactions at the singl...

Higher AMPK activation in mouse oxidative compared with glycolytic muscle does not correlate with LKB1 or CaMKKβ expression

Romain Bernasconi, Kärol Soodla, Alex Sirp, Kairit Zovo, Maria Kuhtinskaja, Tiit Lukk, Marko Vendelin, Rikke Birkedal

Am J Physiol Endocrinol Metab, 2025 Jan 01; 328(1): E...

Compartmentalization in cardiomyocytes modulates creatine kinase and adenylate kinase activities

Rikke Birkedal, Jelena Branovets, Marko Vendelin

FEBS Lett, 2024 Nov; 598(21): 2623-2640.

• PMID: 39112921
• DOI: 10.1002/1873-3468.14994

Significance

Heart muscle cells contain densely pa...

Simple Analysis of Gel Images With IOCBIO Gel Software

Lucia Jaska, Rikke Birkedal, Martin Laasmaa, Marko Vendelin

Bio Protoc, 2024 Aug 20; 14(16): e5053.

• PMID: 39210956
• DOI: 10.21769/BioProtoc.5053

Significance

Gel images are widely used in biology, but results can be hard to rep...

Congratulations to Triinu Rätsepso on defending her bachelor's thesis, Sarcolipin expression in cardiac and skeletal muscles from creatine deficient mice, based on work in the Laboratory of Systems Biology.

Supervised by Rikke Birkedal, Triinu's work examined the expression of sarcolipin in card...

Congratulations to three students from the Laboratory of Systems Biology who defended their theses in TalTech's Applied Physics programme between 3 and 5 June.

Cärolin Grahv defended her master's thesis, A Bayesian approach for super-resolution microscopy image reconstruction. Supervised by Mart...

Simple analysis of gel images with IOCBIO Gel

Jaak Kütt, Georg Margus, Lauri Kask, Triinu Rätsepso, Kärol Soodla, Romain Bernasconi, Rikke Birkedal, Priit Järv, Martin Laasmaa, Marko Vendelin

BMC Biol, 2023 Oct 20; 21(1): 225.

• PMID: 37864184
• DOI: 10.1186/s12915-023-01734-8

Significa

Cardiomyocytes from female compared to male mice have larger ryanodine receptor clusters and higher calcium spark frequency

Martin Laasmaa, Jelena Branovets, Jekaterina Stolova, Xin Shen, Triinu Rätsepso, Mihkel Jaan Balodis, Cärolin Grahv, Eliise Hendrikson, William Edward Louch, Rikke Birkedal,...

Congratulations to Kärol Soodla on defending her bachelor's thesis, Links between energetics and muscle phenotype: pure creatine deficiency leads to skeletal muscle atrophy and shift in myosin heavy chain composition.

Supervised by Romain Bernasconi and Rikke Birkedal Nielsen, Kärol's work exami...